Very often, such changes may cause disturbance and may easily be taken for some suspicious, illegal or virus-triggered activities but the truth is that this software is programmed to operate this way and to aggressively advertise the tools, toolbars, domains, products, and services of different online-based businesses which seek to gain more traffic and clicks.
These are usually the first symptoms which may indicate that you are dealing with a PUP. Advanced Mac Tuneup may install some new homepage domain, a toolbar or a new search engine as well as to integrate some ad-generating and page-redirecting elements inside the browser, without asking for approval.